Cell surface GRP78 promotes stemness in normal and neoplastic cells
نویسندگان
چکیده
منابع مشابه
Normal and Neoplastic Stem Cells
A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation. Research in our laboratory has explored similarities and differences in emb...
متن کاملDeath in normal and neoplastic cells.
It is well known that cell loss occurs from growing neoplasms in vivo. This is particularly prominent in slowly growing tumours, including many human examples (Steel, 1967), and in some cases the rate of cell loss may be as much as 80% of the rate of cell production (Terz, Curutchet, and Lawrence, 1971). Whilst metastasis and desquamation may account for some of the observed cell loss much of i...
متن کاملNeoplastic and Normal Cells in Culture
Despite intensive efforts for several decades, our understanding of tumor cell biology is at the stage where we are still trying to formulate the basic questions involved. We have found that neoplastic cells have subtle alterations in such fundamental processes as cell proliferation, differentiation, and morphogenesis, areas only barely understood in normal cells. Nevertheless, a great deal has...
متن کاملCell-surface GRP78 facilitates colorectal cancer cell migration and invasion.
Glucose regulated protein 78 (GRP78) is predominantly located in the endoplasmic reticulum as a molecular chaperone. It has also been found on the membranes of some cancer cells, acting as a receptor for a wide variety of ligands. However, its presence on colorectal cancer (CRC) cell surface and its role in CRC metastatic progression remain elusive. Here we reported that GRP78 was predominantly...
متن کاملPatterned polymer matrix promotes stemness and cell-cell interaction of adult stem cells
BACKGROUND The interaction of stem cells with their culture substrates is critical in controlling their fate and function. Declining stemness of adult-derived human mesenchymal stem cells (hMSCs) during in vitro expansion on tissue culture polystyrene (TCPS) severely limits their therapeutic efficacy prior to cell transplantation into damaged tissues. Thus, various formats of natural and synthe...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-60269-y